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Table 5 Putative hyaluromycin biosynthetic gene cluster and the neighboring genes

From: Draft genome sequence of Streptomyces hyaluromycini MB-PO13T, a hyaluromycin producer

Orf1- Size (aa) Proposed function Closest homolog Homolog (I/S, %) in
Description, Origin, Accession number I/Sb (%) grh cluster rub cluster
769 230 cyclase hypothetical protein, Streptomyces fulvoviolaceus, WP_052425082 54/63 RubK (53/63)
768a 656 ABC transporter ATP-binding protein multidrug ABC transporter ATP-binding protein, Actinopolymorpha alba, WP_020576731 70/83
767a 577 multidrug ABC transporter ATPase multidrug ABC transporter ATPase, Streptomyces varsoviensis, WP_030881385 69/81
766a 117 MarR family transcriptional regulator MarR family transcriptional regulator, Actinomadura macra, WP_067468911 45/63
765a 72 unknown hypothetical protein, Streptomyces aurantiacus, WP_055507532. 56/60
764a 498 transcriptional regulator hypothetical protein, Streptomyces sp. NRRL WC-3742, WP_051836320 55/63 GrhR2 (34/48)  
763a 533 amide synthetase hypothetical protein, partial, Streptomyces sp. NRRL WC-3742, WP_078910860 60/70
762a 405 5-aminolevulinate synthase AsuD2, Streptomyces nodosus subsp. asukaensis, ADI58646 77/85
761 515 5-aminolevulinate CoA ligase AMP-dependent synthetase, Streptomyces uncialis, OKH94380 77/83
760 183 unknown hypothetical protein, Streptomyces prunicolor, WP_019061819 50/60
759 122 unknown hypothetical protein, Streptomyces fulvoviolaceus, WP_030615859 72/82 GrhI (61/73)
758 477 oxygenase hypothetical protein, Streptomyces yerevanensis, WP_033324694 72/82 GrhO1 (72/80) RubI (71/80)
757 257 3-oxoacyl-ACP reductase SDR family oxidoreductase, Streptomyces fulvoviolaceus, WP_030615854 83/92 GrhO2 (73/81) RubJ (83/91)
756 325 acetyltransferase GrhJ, Streptomyces sp. CN48+, AIE76926 68/74 GrhJ (67/73)
755 540 monooxygenase hypothetical protein, Streptomyces prunicolor, WP_026151147 73/80 GrhO5 (69/75) RubL (73/80)
754a 161 transcriptional regulator putative transcriptional repressor GrhR3, Streptomyces sp. CN48+, AIE76928 76/88 GrhR3 (76/88) RubM (74/83)
753 501 monooxygenase RubN, Streptomyces collinus, AAM97364 80/86 GrhO6 (73/80) RubN (80/86)
752 325 oxidoreductase hypothetical protein, Streptomyces sp. TSRI0261, WP_073806081 86/93 GrhO7 (78/89)
751 343 methyltransferase hypothetical protein, Streptomyces fulvoviolaceus, WP_030615823 81/86 GrhL (77/83)
750 535 monooxygenase hypothetical protein, Streptomyces prunicolor, WP_019061807 74/82 GrhO8 (70/79) RubO (63/72)p
749a 534 oxidoreductase hypothetical protein, Streptomyces sp. TP-A0875, WP_053912978 74/80 GrhO9 (71/79) RubP (74/80)
748 161 unknown hypothetical protein, Streptomyces prunicolor, WP_019061805 81/85 GrhM (80/86) RubQ (80/85)
747 174 unknown hypothetical protein, Streptomyces fulvoviolaceus, WP_030615810 67/74 GrhN (56/64) RubW (64/74)
746 623 asparagine synthase RubR, Streptomyces collinus, AAM97368 80/86 GrhP (74/81) RubR (80/86)
745 669 transcriptional regulator RubS, Streptomyces collinus, AAM97369 63/75 GrhR2 (43/56) RubS (63/75)
744 123 cyclase putative cyclaseI, Streptomyces collinus, AAG03065 83/88 GrhQ (75/88) RubE (83/88)
743 143 cyclase cupin, Streptomyces sp. TSRI0261, OKJ01252 83/90 GrhS (66/77) RubD (79/85)
742 424 ketosynthase α subunit type II polyketide synthase 4, Streptomyces sp., APD71740 89/95 GrhA (85/91) RubA (89/93)
741 420 ketosynthase β subunit type II polyketide synthase 5, Streptomyces sp., APD71741 82/88 GrhB (76/83) RubB (79/85)
740 87 acyl carrier protein acyl carrier protein, Streptomyces collinus, AAG03069 68/79 GrhC (34/61) RubC (68/79)
739 398 cyclase/reductase hypothetical protein, Streptomyces prunicolor, WP_019061796 79/87 GrhT (67/78) RubF (78/85)
738 249 ketoreductase SDR family oxidoreductase, Streptomyces prunicolor, WP_019061795 86/94 GrhO10 (79/89) RubG (86/93)
737 108 monooxygenase hypthetical protein, Streptomyces collinus, AAG03072 88/93 GrhU (75/84) RubH (88/93)
736 113 unknown hypothetical protein, Streptomyces fulvoviolaceus, WP_078655944 73/80 GrhV (67/76) RubT (70/81)
735 417 cytochrome P450 cytochrome P450, Streptomyces fulvoviolaceus, WP_030615776 80/86 GrhO3 (37/53) RubU (80/86)
734 301 unknown DUF1963 domain-containing protein, Streptacidiphilus carbonis, WP_042397320 78/85
733 155 cupin cupin, Streptomyces prunicolor, WP_019056246 93/97
732 322 esterase alpha/beta hydrolase, Actinobacteria bacterium OK074, KPI24488 83/88
731 313 transcriptional regulator transcriptional regulator, Streptomyces hokutonensis, WP_043260174 79/85
730a 491 unknown dolichyl-phosphate-mannose-protein mannosyltransferase, Micromonospora auratinigra, SBT53146 57/67
729 42 unknown
728a 333 transcriptional regulator LacI family transcriptional regulator, ‘Streptomyces humi’, WP_046734674 93/96
  1. aencoded in complementary strand, bI/S, identity/similarity. Orf1-763 also shows 48% sequence identity/61% sequence similarity to AsuD1 of Streptomyces nodosus subsp. asukaensis (ADI58645); Orf1-761 shows 73% sequence identity/81% sequence similarity to AsuD3 of S. nodosus subsp. asukaensis (ADI58647)