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Table 6 Proposed mechanism to produce lydicamycin congeners

From: Draft genome sequence of marine-derived Streptomyces sp. TP-A0598, a producer of anti-MRSA antibiotic lydicamycins

congener

substrate of m3 AT m

m11 ER

CYP450

lydicamycin

methylmalonyl-CoA

active

involved

TPU-0037-A

malonyl-CoA

active

involved

TPU-0037-B

methylmalonyl-CoA

inactive

uninvolved

TPU-0037-C

malonyl-CoA

active

uninvolved

TPU-0037-D

methylmalonyl-CoA

active

uninvolved

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Environmental Microbiome

ISSN: 2524-6372