Skip to main content

Table 4. Metagenomics annotation hierarchy.

From: The JCVI standard operating procedure for annotating prokaryotic metagenomic shotgun sequencing data

Annotation Rank

Evidence Type

Evidence Class

1

HMM

TIGRfam Equivalog

2

HMM

Pfam Equivalog

3

HMM

TIGRfam Hypothetical Equivalog

4

HMM

Pfam Hypothetical Equivalog

5

HMM

TIGRfam Domain

6

PRIAM

PRIAM

7

HMM

TIGRfam Subfamily

8

HMM

TIGRfam Superfamily

9

HMM

TIGRfam EquivalogDomain

10

HMM

TIGRfam Hypothetical Equivalog Domain

11

HMM

TIGRfam Subfamily Domain

12

HMM

Pfam Subfamily

13

HMM

Pfam Superfamily

14

HMM

Pfam Equivalog Domain

15

HMM

Pfam Hypothetical Equivalog Domain

16

HMM

Pfam Subfamily Domain

17

BLAST

Panda BLASTP High Confidence

18

HMM

TIGRfam Domain

19

HMM

Pfam Domain

20

HMM

Pfam Uncharacterized

21

BLAST

Panda BLASTP Putative

22

BLAST

Panda BLASTP Conserved Domain

23

TMHMM

TMHMM

24

LIPOPROTEIN

Lipoprotein Motif

25

DEFAULT

Hypothetical

  1. This hand-curated and validated list, derived from years of experience with prokaryotic ge-nome analysis, allows for the best-supported conservative functional annotation based on the available homology-based evidence and computational assertions.