Skip to main content
Figure 1. | Standards in Genomic Sciences

Figure 1.

From: Quantifying Protein Function Specificity in the Gene Ontology

Figure 1.

Function specificity in the GO. This graph illustrates, using a simplified model of the GO hierarchy, how the number of ancestors (Ancestors) and offspring (Offspring) for GO terms would be calculated. For calculating IC, the number of proteins with a particular GO term annotation must be accounted for in determining their probability of occurring in the data set (Proteins). The probability of a term occurring depends on whether or not a particular term or any of its offspring terms occurs in a data set (Total Proteins). Details on how each specificity measure is calculated can be found in the “Procedures” section.

Back to article page