|
Gene cluster
|
Encoded in
|
No. of modular PKS and NRPS genes
|
No. of modules
|
Backbone of predicted product
|
|---|
|
pks/nrps-1 (rak)
|
scaffold 2
|
6
|
7
|
R-C3-C3
a-Ser-C2-Gly-X
|
|
pks/nrps-2
|
scaffold 2
|
6
|
6
|
X-X-X-?-C2-Ser
|
|
pks/nrps-3
|
scaffold 2
|
5
|
6
|
X-X-?-C2-Asn-Ser
|
|
pks-1
|
scaffold 2
|
12
|
33
|
R-C2-C3-C2-C2-C2-C2-C2-C4-C2-C2-C2-C2-C2-C2-C2-C2-C2-C?-C2-C3-C2-C2-C3-C2-C3-C3-C2-C3-C3-C3-C2-C2
|
|
pks-2
|
scaffold 5
|
1
|
1
|
C2
|
|
pks-3
|
scaffold 24
|
1
|
1
|
C2
|
|
nrps-1
|
scaffold 2
|
2
|
2
|
X-Ala
|
-
R starter molecule, C
3
C3 unit derived from methylmalonyl-CoA, C
2
C2 unit derived from malonyl-CoA, X amino acid unpredicted, ? lack of A domain in the NRPS module, C
4
C4 unit derived from ethylmalonyl-CoA or methoxymaronyl-CoA, C
?
substrate of AT domain was not predicted
-
aAlthough antiSMASH predicted that the AT domain incorporates malonyl-CoA as the substrate, the signature sequence for substrate determination is not HAFHS for malonyl-CoA but TSSHS likely for methylmaronyl-CoA [33]
