Skip to main content

Table 5 Modular PKS and NRPS gene clusters in Streptomyces sp. MWW064

From: Draft genome sequence of Streptomyces sp. MWW064 for elucidating the rakicidin biosynthetic pathway

Gene cluster Encoded in No. of modular PKS and NRPS genes No. of modules Backbone of predicted product
pks/nrps-1 (rak) scaffold 9 6 7 R-C3-C3-Ser-C2-Gly-X
pks/nrps-2 scaffold 5 6 14 C2-C2-C2-C2-C2-Gly-C2-C2-C2-C2-C2-C2-C2-C2
pks/nrps-3 scaffold 2 4 3 C?-C?-X
pks/nrps-4 scaffold 11 1 2 X-C2
pks-1 scaffold 18 5 5 C?-C3-C2-C2-C?
pks-2 scaffold 23 1 1 C?
other pks a scaffolds 11, 39, 45 >3 >10 C2-C2-C3-C2, C2-C2, C2-C2-C2, C2
nrps-1 scaffold 11 4 4 X-X-Val-X
nrps-2 scaffold 18 3 3 R-Val-X
nrps-3 scaffold 9 2 3 R-Cys-mCys
nrps-4 scaffold 13 3 4 Val-Gly-Ser-Pro
nrps-5 scaffold 2 1 1 Ser
nrps-6 scaffold 12 1 1 Thr
other nrps a scaffolds 3, 5 >2 >6 X-X-X-X-X, Cys
  1. anot completely sequenced. R, starter unit; C3, C3 unit derived from methylmalonyl-CoA; C2, C2 unit derived from malonyl-CoA; X, unpredictable amino acid; C?, unpredictable carbon unit derived from acyl-CoA; mCys, methylated cysteine