Table 5 Identified antibiotic resistances and their putative genetic background
Antibiotic | Class | Encoded resistance genes; locus |
|---|---|---|
amoxicillin/clavulanic acid | β-lactam + β-lactamase inhibitor | metallo-β-lactamase, PcP3B5_32180 class A β-lactamase, PcP3B5_44400 metallo-β-lactamase, PcP3B5_46940 metallo-β-lactamase, PcP3B5_47300 class C β-lactamase, PcP3B5_53150 |
cefotaxime | β-lactam/third generation cephalosporin | |
cefoxitin | β-lactam/second generation cephalosporin | |
cefpodoxime | β-lactam/third generation cephalosporin | |
cefuroxime | β-lactam/second generation cephalosporin | |
cephalothin | β-lactam/second generation cephalosporin | |
temocillin | β-lactam/β-lactamase-resistant penicillin | |
aztreonam | monobactam antibiotic | class C β-lactamase, PcP3B5_53150 |
lincosamide | intrinsic resistance | |
vancomycin | intrinsic resistance | |
minocycline | tetracycline antibiotic | tetA, PcP3B5_30660 |
rifamycin SV | rifamycin | intrinsic resistance, no resistance genes detected |
trimethoprim | sulfonamide antibiotic | multidrug efflux pump OprM1-5; PcP3B5_05670, PcP3B5_32430, PcP3B5_35160, PcP3B5_36300, PcP3B5_37480 |
trimethoprim/sulfamethoxazole | dihydrofolate reductase inhibitor/sulfonamide antibiotic | |
nitrofurantoin | nitrofuran derivative | intrinsic resistance and vanX; PcP3B5_55530 |
fosfomycin | N-acetylmuramic acid synthesis inhibition | fosA; PcP3B5_27860 |