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Figure 6 | Standards in Genomic Sciences

Figure 6

From: Genome sequence of Clostridium sporogenes DSM 795T, an amino acid-degrading, nontoxic surrogate of neurotoxin-producing Clostridium botulinum

Figure 6

Genome comparison of C. sporogenes with different C. sporogenes and C. botulinum strains: A: Genes encoded by the leading and the lagging strand (circle 1 and 2) of C. sporogenes DSM 795 are marked in COG colors in the artificial chromosome map. The presence of orthologs (circle 3 to 10) is indicated for the genomes of C. sporogenes PA3679 (AGAH00000000), C. sporogenes ATCC 15579 (ABKW00000000) , C. botulinum ATCC 3502 (CP000727.1), C. botulinum B1 str. Okra (CP000939.1, CP000940.1), C. botulinum F str. Langeland (CP000728.1, CP000729.1), C. botulinum E3 str. Alaska E43 (CP001078.1), C. botulinum D str. 1873 (ACSJ01000001), C. botulinum C str. Eklund (ABDQ01000001) are illustrated in red to light yellow and singletons in grey (grey: >e−10-1; light yellow: <e−50- > e−10; gold: <e−50- > e−90; light orange: <e−90- > e−100; orange: <e−100- > e−120; red: <e−120-0). The two innermost plots represent the GC-content and the GC-skew. The artificial chromosome was built after scaffolding with Mauve alignment tool and concatenating the 16 contigs of the draft genome. Venn diagrams showing orthologs genes between the three sequenced C. sporogenes species (B) and between C. sporogenes DSM 795, the phylogenetic closely related C. botulinum ATCC 3502 and distantly related C. botulinum E3 str. Alaska E43 (C). Ortholog detection was done with the Proteinortho software (blastp) with an identity cutoff of 50% and an E-value of 1e-10. The total number of genes and paralogs, respectively, were depicted under the corresponding species name.

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